Relevance of electrolytes, creatinine and uric acid in progression of type 2 diabetes mellitus in Bangladeshi population

Atiar  Rahman; Shahnowaj  Bhuyian; Areeful Haque; Dina  Hajjare; Walla  Alelwanie; Arwa  A. Makkie

Authors

Atiar Rahman University of Chittagong, Bangladesh
Shahnowaj Bhuyian University of Chittagong, Bangladesh
Areeful Haque University Chittagong, Bangladesh
Dina Hajjare University of Jeddah, Saudi Arabia
Walla Alelwanie University of Jeddah, Saudi Arabia
Arwa A. Makkie University of Jeddah, Saudi Arabia

Keywords:

Creatinine, HbA1c, serum electrolytes, type 2 diabetic mellitus, uric acid, URCA

Abstract

Background: Type 2 diabetes is a chronic metabolic syndrome, with partial beta cell dysfunction, that can lead to serious cardiovascular, renal, neurologic and retinal complications. The knowledge on the diabetic disorders in electrolytes and membrane function in Bangladeshi population is limited.

Objective: This research aimed to analyze the association of serum uric acid, creatinine, and electrolytes as potential risk factors for developing type 2 diabetes mellitus in Bangladeshi population.

Methods: The research performed a prospective case-control study of 79 uncontrolled and 60 controlled type 2 diabetic subjects. Subject’s serum was analyzed for electrolytes, glucose, creatinine, uric acid, and HbA1c applying electrolytes analyzer system, glucose-oxidase method, alkaline picrate method, ultraviolet-visible spectrophotometric method, unit root and cointegration analysis (URCA) method based on dimension clinical chemistry system and turbidimetric inhibition immunoassay method (TINIA), respectively.

Results: At the experimental period, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the uncontrolled type 2 diabetes subjects were significantly different (P < 0.05) from those of the controlled type 2 diabetes subjects. HbA1c, sodium ion, potassium ion, bicarbonate ion, serum uric acid level in the uncontrolled type 2 diabetes subjects and the controlled type 2 diabetes subjects were significantly different from those of the controlled type 2 diabetes subjects. However, serum creatinine in the uncontrolled type 2 diabetes subjects and the controlled type 2 diabetes subjects were 1.08 - 0.94 and 1.06 - 0.35 mg/dl, respectively. This showed no significant difference. Na⁺, K⁺, uric acid and HCO₃ - are negatively associated with the uncontrolled type 2 diabetes and Cl- is positively associated with the controlled type 2 diabetes.

Conclusion: Progression of type 2 diabetes is positively correlated with the increase of glycosylated hemoglobin, uric and creatinine in Bangladeshi population.

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