Acute psychosis in patient with hydroxyurea-induces anemia

Authors

  • Nichkamol Kittipavara Faculty of Medicine Vajira Hospital, Bangkok, Thailand
  • Wisarat Pruttithavorn Faculty of Medicine Vajira Hospital, Bangkok, Thailand

Keywords:

Essential thrombocythemia, hydroxyurea, psychosis, psychotic disorder

Abstract

A 65-year-old Thai woman with underlying essential thrombocythemia (ET) presented with acute psychosis. Hydroxyurea has been used in the patient with ET to reduce the frequency and severity of thrombotic complications of the disease. Its side effect is anemia which is almost always reversible and will go away after the treatment is completed. In this case report, the psychotic symptoms happened with no other specific causes. This novel evidence suggests the possibility of the association between hydroxyurea and anemia.

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References

Cortelazzo S, Finazzi G, Ruggeri M, Vestri O, Galli M, Rodeghiero F, et al. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med 1995;332:1132-6.

https://doi.org/10.1056/NEJM199504273321704

Jabr FI, Shamseddine A, Taher A. Hydroxyureainduced hemolytic anemia in a patient with essential thrombocythemia. Am J Hematol 2004;77:374-6.https://doi.org/10.1002/ajh.20222

Puangthong U, Pongpirul K. Chemotherapy-induced acute psychosis in a patient with malignant germ cell tumour. BMJ Case Rep 2015;2015. pii: bcr2014208982. https://doi.org/10.1136/bcr-2014-208982

Johnson-Spear MA, Yip R. Hemoglobin difference between black and white women with comparable iron status: Justification for race-specific anemia criteria. Am J Clin Nutr 1994;60:117-21.

https://doi.org/10.1093/ajcn/60.1.117

World Health Organization. Haemoglobin concen trations for the diagnosis of anaemia and assessment of severity [Internet]. 2011 [cited 2019 Sep 29]. Available from: https://www.who.int/vmnis/indicators/ haemoglobin/en/.

Keshavan MS, Kaneko Y. Secondary psychoses: An update. World Psychiatry 2013;12:4-15.

https://doi.org/10.1002/wps.20001

Romano J, Evans JW. Symptomatic psychosis in a case of secondary anemia. Arch Neur Psych 1938;39: 1294-301. https://doi.org/10.1001/archneurpsyc.1938.02270060184011

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Published

2023-08-03

How to Cite

1.
Kittipavara N, Pruttithavorn W. Acute psychosis in patient with hydroxyurea-induces anemia. Chula Med J [Internet]. 2023 Aug. 3 [cited 2024 Nov. 22];64(4). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/261