Gross and histopathologies of thyroid gland in cadavers from the South of Thailand

Authors

  • Pornsawan Duangsuwan Faculty of Science, Prince of Songkla University
  • Walaiporn Plirat Faculty of Science, Prince of Songkla University
  • Anupong Nitiruangjaras Faculty of Science, Prince of Songkla University
  • Wattana Sinkijcharoenchai Faculty of Science, Prince of Songkla University

Keywords:

Thyroid gland, gross pathology, histopathology, cadaver, nodular goiter, multinodular goiter, Hashimoto thyroiditis, Grave’s disease

Abstract

Background : Thyroid gland is highly vascular, a butterfly-shaped endocrine gland, located in the front part of the neck. It plays an important role in releasing hormones that control the metabolism. The thyroid glands in cadavers were well preserved by embalming materials and could be sectioned for histopathological diagnosis.

Objective : To investigate abnormalities of thyroid glands of cadavers from the South of Thailand.

Methods : Gross and histological assessment of thyroid glands were studied in 102 (42 females and 60 males) cadavers of the Department of Anatomy, Faculty of Science, Prince of Songkla University. Statistical analysis was done using SPSS 16.0 statistical software.

Results : Histologically, the thyroid gland specimens from cadaver revealed satisfactory microscopic features of cells and connective tissues under paraffin section with hematoxylin and eosin staining. Five types of histopathology were diagnosed: nodular goiter, multinodular goiter, Hashimoto thyroiditis, mixed nodular goiter/Hashimoto thyroiditis and Grave’s disease, with prevalence at 20.6%, 17.7%, 4.9%, 2.0% and 2.9%, respectively. Specimens from the females showed significantly higher prevalence of multinodular goiter than those form the males.

Conclusion : The prevalence of the five thyroid conditions diagnosed form cadavers’ specimens were much higher than those reported in clinical studies, suggesting a high possibility of subclinical cases of thyroid dysfunctions in normal population.

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References

Moore KL, Dalley AF, Agur AMR. Clinically Oriented Anatomy. 8th ed. Philadelphia: Wolter Kluwer; 2018, p.1018-9.

Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 2008;22:901-11. https://doi.org/10.1016/j.beem.2008.09.019

Salab GB. Pathogenesis of thyroid nodules:histological classification? Biomed Pharmacother 2001;55:39-53. https://doi.org/10.1016/S0753-3322(00)00010-X

Chatyingmongkol K, Roongruangchai J, Pilakasiri K, Kerdpurch K. The ultrastructure of the parathyroid gland in cadaveric embalmed specimens. Siriraj Med J 2008;60:7-9.

Poddar R, Bhattacharya A, Ghosal AK, Biswas S. Morphometric study of human thyroid gland with emphasis on pyramidal lobe - a cadaverbased study on eastern Indian population. Indian J Basic Appl Med Res 2017;6:92-100.

Akamizu T, Amino N. Hashimoto's Thyroiditis. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com; 2000. [Updated 2017 Jul 17; cited cited 2018 Feb 15]. Available from: https://www.ncbi.nlm.nih. gov/books/NBK285557/.

Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia: Saunder Elsevier; 2010.

Lee J, Yi S, Kang YE, Kim H-W, Joung KH, Sul HJ, et al. Morphological and functional changes in the thyroid follicles of the aged murine and humans. J Pathol Transl Med 2016;50:426-35.

https://doi.org/10.4132/jptm.2016.07.19

Tunbridge WGM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol 1977; 7:481-93.

https://doi.org/10.1111/j.1365-2265.1977.tb01340.x

Charib TGH. Thyroid incidentalomas: management approaches to non-palpable nodules discovered incidentally on thyroid imaging. Ann Int Med 1997;126:226-31.

https://doi.org/10.7326/0003-4819-126-3-199702010-00009

Gharib H, Papini E. Thyroid Nodules: Clinical importance, assessment, and treatment. Endocrinol Metab Clin North Am 2007;36:707-35. https://doi.org/10.1016/j.ecl.2007.04.009

Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull 2011;99:39-51.

https://doi.org/10.1093/bmb/ldr030

Vanderpump MPJ, Tunbrldge WMG, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995;43:55-68. https://doi.org/10.1111/j.1365-2265.1995.tb01894.x

Vanderpump MPJ, Tunbridge WMG. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid 2002;12:839-47. https://doi.org/10.1089/105072502761016458

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Published

2023-08-16

How to Cite

1.
Duangsuwan P, Plirat W, Nitiruangjaras A, Sinkijcharoenchai W. Gross and histopathologies of thyroid gland in cadavers from the South of Thailand. Chula Med J [Internet]. 2023 Aug. 16 [cited 2024 Nov. 6];62(3). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/347