Premature ejaculation.

Authors

  • K. Tantiwongse King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.
  • S. Srithong King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.

Keywords:

Premature ejaculation, sexual dysfunction, penile disorders

Abstract

Premature ejaculation is a condition in men that has numerous effects on women. It can be identified 20 - 30% in men of every age group. The definition is different in patient perspective. In medical aspect, it could be defined in term of time, controllability, and mental disturbance. Because this condition involves multiple organ systems but more on neurological system and erectile tissue of the penis. Most studies aimed to understand the mechanism of erection and ejaculation. After then treatments could be applied on every step of the ejaculation pathway: the brain as a main sensory and motor control, the spinal cord and nerves as a signal transducer, and peripheral nerves at the penis as an input and output impulses. The medical treatments involve the control of sympathetic nervous system and decrease penile sensation. Surgical management mainly desensitized the dorsal nerve of the penis. The outcome of each technique varies in the success rate and all need long term follow up.

Downloads

Download data is not yet available.

References

Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol 2007;51:816-23. https://doi.org/10.1016/j.eururo.2006.07.004

McMahon CG, Lee G, Park JK, Adaikan PG. Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region. J Sex Med 2012;9:454-65.

https://doi.org/10.1111/j.1743-6109.2011.02507.x

Vignozzi L, Filippi S, Morelli A, Luconi M, Jannini E, Forti G, et al. Regulation of epididymal contractility during semen emission, the first part of the ejaculatory process: a role for estrogen. J Sex Med 2008;5:2010-6 https://doi.org/10.1111/j.1743-6109.2008.00914.x

Giuliano F, Clement P. Neuroanatomy and physiology of ejaculation. Annu Rev Sex Res 2005;16:190-216.

Peeters M, Giuliano F. Central neurophysiology and dopaminergic control of ejaculation. Neurosci Biobehav Rev 2008;32:438-53. https://doi.org/10.1016/j.neubiorev.2007.07.013

Waldinger MD, Schweitzer DH. The use of old and recent DSM definitions of premature ejaculation in observational studies: a contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med 2008;5:1079-87. https://doi.org/10.1111/j.1743-6109.2008.00789.x

Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebocontrolled study. Am J Psychiatry 1994;151:1377-9.

https://doi.org/10.1176/ajp.151.9.1377

Lee WK, Cho ST, Lee YS, Lee YG, Oh CY, Yoo C, et al. Can estimated intravaginal ejaculatory latency time be used interchangeably with stopwatch-measured intravaginal ejaculatory latency time for the diagnosis of lifelong premature ejaculation? Urology 2015;85: 375-80.

https://doi.org/10.1016/j.urology.2014.09.036

Rosen RC, McMahon CG, Niederberger C, Broderick GA, Jamieson C, Gagnon DD. Correlates to the clinical diagnosis of premature ejaculation: results from a large observational study of men and their partners. J Urol 2007;177:1059-64. https://doi.org/10.1016/j.juro.2006.10.044

Waldinger MD, McIntosh J, Schweitzer DH. A five-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population. J Sex Med 2009;6:2888-95.

https://doi.org/10.1111/j.1743-6109.2009.01392.x

Moon DG, Kwak TI, Cho HY, Bae JH, Park HS, Kim JJ. Augmentation of glans penis using injectable hyaluronic acid gel. Int J Impot Res 2003;15:456-60. https://doi.org/10.1038/sj.ijir.3901058

Larsen NE, Poliak CT, Reiner K, Leshchiner E, Balazs EA. Hylan gel biomaterial: dermal and immunologic compatibility. J Biomed Mater Res 1993;27:1129-34.

https://doi.org/10.1002/jbm.820270903

Elson ML. Soft tissue augmentation. A review. Dermatol Surg 1995;21:491-500.

https://doi.org/10.1111/j.1524-4725.1995.tb00252.x

Pollack SV. Silicone, fibrel, and collagen implantation for facial lines and wrinkles. J Dermatol Surg Oncol 1990;16:957-61. https://doi.org/10.1111/j.1524-4725.1990.tb01560.x

Moon du G, Kwak TI, Kim JJ. Gians penis augmentation using hyaluronic acid gel as an injectable filler. World J Mens Health 2015; 33:50-61. https://doi.org/10.5534/wjmh.2015.33.2.50

Abdallah H, Abdelnasser T, Hosny H, Selim O, Al-Ahwany A, Shamloul R. Treatment of premature ejaculation by glans penis augmentation using hyaluronic acid gel: a pilot study. Andrologia 2012;44 Suppl 1: 650-3. https://doi.org/10.1111/j.1439-0272.2011.01244.x

Littara A, Palmieri B, Rottigni V, Iannitti T. A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. Int J Impot Res 2013;25:117-20.

https://doi.org/10.1038/ijir.2013.13

Kwak TI, Jin MH, Kim JJ, Moon DG. Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation. Int J Impot Res 2008;20:425-8.

https://doi.org/10.1038/ijir.2008.26

Zhang GX, Yu LP, Bai WJ, Wang XF. Selective resection of dorsal nerves of penis for premature ejaculation. Int J Androl 2012;35: 873-9. https://doi.org/10.1111/j.1365-2605.2012.01296.x

Yang DY, Ko K, Lee WK, Park HJ, Lee SW, Moon KH, et al. Urologist's practice patterns including surgical treatment in the management of premature ejaculation: A Korean Nationwide Survey. World J Mens Health 2013;31:226-31. https://doi.org/10.5534/wjmh.2013.31.3.226

David Prologo J, Snyder LL, Cherullo E, Passalacqua M, Pirasteh A, Corn D. Percutaneous CT-guided cryoablation of the dorsal penile nerve for treatment of symptomatic premature ejaculation. J Vase Interv Radiol 2013;24:214-9. https://doi.org/10.1016/j.jvir.2012.09.015

McMahon CG. Current and emerging treatments for premature ejaculation. Sex Med Rev 2015; 3:183-202. https://doi.org/10.1002/smrj.49

Hawton K, Catalan J. Prognostic factors in sex therapy. Behav Res Ther 1986;24:377-85.

https://doi.org/10.1016/0005-7967(86)90002-1

Hawton K, Catalan J, Martin P, Fagg J. Longterm outcome of sex therapy. Behav Res Ther 1986;24:665-75. https://doi.org/10.1016/0005-7967(86)90062-8

McMahon CG. Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol 2012;4:233-51. https://doi.org/10.1177/1756287212453866

Dresser MJ, Kang D, Staehr P, Gidwani S, Guo C, Mulhall JP, et al. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal. J Clin Pharmacol 2006;46: 1023-9. https://doi.org/10.1177/0091270006291033

McMahon CG, Althof SE, Kaufman JM, Buvat J, Levine SB, Aquilina JW, et al. Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials. J Sex Med 2011;8:524-39. https://doi.org/10.1111/j.1743-6109.2010.02097.x

Yue FG, Dong L, Hu TT, Qu XY. Efficacy of dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events. Urology 2015;85: 856-61. https://doi.org/10.1016/j.urology.2015.01.009

Cormio L, Massenio P, La Rocca R, Verze P, Mirone V, Carrieri G. The combination of dapoxetine and behavioral treatment provides better results than dapoxetine alone in the management of patients with lifelong premature ejaculation. J Sex Med 2015;12: 1609-15. https://doi.org/10.1111/jsm.12925

Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 2004;16:369-81. https://doi.org/10.1038/sj.ijir.3901172

Waldinger MD. Premature ejaculation: definition and drug treatment. Drugs 2007;67:547-68.

https://doi.org/10.2165/00003495-200767040-00005

Marangell LB, Dennehy EB, Wisniewski SR, Bauer MS, Miyahara S, Allen MH, et al. Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD.J Clin Psychiatry 2008;69:916-22.

https://doi.org/10.4088/JCP.v69n0605

Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebocontrolled, fixed-dose, randomized study. J Clin Psychopharmacol 2006;26:27-31. https://doi.org/10.1097/01.jcp.0000195110.79027.3f

Lintz W, Erlacin S, Frankus E, Uragg H. Biotransformation of tramadol in man and animal (author's transl)]. Arzneimittelforschung 1981;31:1932-43.

Epstein DH, Preston KL, Jasinski DR. Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol. Biol Psychol 2006;73:90-9. https://doi.org/10.1016/j.biopsycho.2006.01.010

Kurkar A, Elderwy AA, Abulsorour S, Awad SM, Safwat AS, Altaher A. A randomized, doubleblind, placebo-controlled, crossover trial of "on-demand" tramadol for treatment of premature ejaculation. Urol Ann 2015;7: 205-10. https://doi.org/10.4103/0974-7796.150481

Martyn-St James M, Cooper K, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, et al. Tramadol for premature ejaculation: a systematic review and meta-analysis. BMC Urol 2015;15:6.

https://doi.org/10.1186/1471-2490-15-6

Eassa BI, El-Shazly MA. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl 2013; 15:138-42. https://doi.org/10.1038/aja.2012.96

Li X, Zhang SX, Cheng HM, Zhang WD. Clinical study of sildenafil in the treatment of premature ejaculation complicated by erectile dysfunction. Zhonghua Nan Ke Xue 2003;9: 266-9.

McMahon CG, Stuckey BG, Andersen M, Purvis K, Koppiker N, Haughie S, et al. Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2005;2:368-75.

https://doi.org/10.1111/j.1743-6109.2005.20351.x

Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med 2010;7:3572-88.

https://doi.org/10.1111/j.1743-6109.2010.02062.x

Wyllie MG, Powell JA. The role of local anaesthetics in premature ejaculation. BJU Int 2012;110:E943-8.

https://doi.org/10.1111/j.1464-410X.2012.11323.x

Gur S, Sikka SC. The characterization, currentmedications, and promising therapeutics targets for premature ejaculation. Andrology 2015;3:424-42. https://doi.org/10.1111/andr.12032

Atikeler MK, Gecit I, Senol FA. Optimum usage of prilocaine- lidocaine cream in premature ejaculation. Andrologia 2002;34:356-9. https://doi.org/10.1046/j.1439-0272.2002.00511.x

Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, et al. Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 2007;99:369-75. https://doi.org/10.1111/j.1464-410X.2006.06583.x

Choi HK, Jung GW, Moon KH, Xin zc, Choi YD, Lee WH, et al. Clinical study of SS-cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. https://doi.org/10.1016/S0090-4295(99)00415-X

Linton KD, Wylie KR. Recent advances in the treatment of premature ejaculation. Drug Des Devel Ther 2010;4:1-6. https://doi.org/10.2147/DDDT.S6077

Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60-90. https://doi.org/10.1002/sm2.28

Downloads

Published

2023-08-18

How to Cite

1.
Tantiwongse K, Srithong S. Premature ejaculation. Chula Med J [Internet]. 2023 Aug. 18 [cited 2024 Oct. 12];62(5). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/392