Relationship of serum leptin and 25-hydroxyvitamin D in knee osteoarthritis patients

Authors

  • Pacharee Manoy Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • Wilai anomasiri Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • Pongsak Yuktanandana Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • Aree Tanavalee Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • Thomas Mabey Institute of Life Sciences, University of Southampton, United Kingdom
  • Sittisak Honsawek Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

Keywords:

Leptin, knee, osteoarthritis, vitamin D

Abstract

Background : Osteoarthritis (OA) is a degenerative articular disease that involves progressive alterations in all joint structures resulting from aging and overuse activity. Leptin and vitamin D play a crucial role in energy metabolism; however, few reports on leptin and 25-hydroxyvitamin D (25(OH)D) in knees of osteoarthritis (OA) has been known.

Objectives : To examine serum levels of leptin and vitamin D in knee OA patients and analyze the possible relationship between serum leptin, 25-hydroxyvitamin D, and clinical parameters in OA patients.

Methods : In a cross-sectional study, 235 adult patients (212 women and 23 men, aged 65.6 gif.latex?\pm 6.5 years) with established diagnosis of OA and 50 healthy controls were recruited. Serum 25(OH)D and serum leptin levels were measured.

Results : Serum vitamin D insufficiency (gif.latex?\leq 30 ng/ml) was found in 48.0% of the patients with OA; whereas serum vitamin D deficiency (gif.latex?\leq 20 ng/ml) was detected in 35.0% of osteoarthritis patients. Serum leptin concentrations were significantly elevated in OA patients when compared with the controls (P = 0.02). There was a negative correlation between serum 25(OH)D concentration and serum leptin in patients with knee OA (P < 0.001) (r = -0.26, P < 0.001).

Conclusions : Vitamin D insufficiency and deficiency is highly prevalent in OA patients and associated with higher serum leptin. These findings suggest that high serum leptin could be used for predicting low vitamin D in knee OA patients.

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Published

2023-08-21

How to Cite

1.
Manoy P, anomasiri W, Yuktanandana P, Tanavalee A, Mabey T, Honsawek S. Relationship of serum leptin and 25-hydroxyvitamin D in knee osteoarthritis patients. Chula Med J [Internet]. 2023 Aug. 21 [cited 2024 Nov. 22];62(6). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/408

Issue

Vol. 62 No. 6 (2018): Chulalongkorn Medical Journal

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Original Articles

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