Prevalence of preoperative delirium and associated factors in elderly hip fracture patients at King Chulalongkorn Memorial Hospital

Authors

  • Warong Sitthisarunkul Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • Yanin Thipakorn Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • Paul Thisayakorn Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Keywords:

Delirium, elderly, hip fracture

Abstract

Background: Preoperative delirium in hip fracture is under-studied. Effective diagnosis, prevention, and management of preoperative delirium may be able to reduce the incidence of the postoperative complications.

Objective: To study the prevalence of preoperative delirium and its associated factors in elderly patients who underwent hip fracture surgery.

Methods: This is a cross-sectional study which collected the data from patients aged more than 65 years who underwent hip surgery at King Chulalongkorn Memorial Hospital. Preoperative cognitive status assessment was done by using the Thai Mental State Examination (TMSE) and The Confusion Assessment Method-Thai (CAM-T) on the day before surgery. The DSM-V criteria for delirium was used to confirm the diagnosis. Postoperative factors were assessed at bedside on day 2 after surgery and on discharge.

Results: There were 104 patients recruited in the study with a mean age of 81.3 years. In total, 24 patients developed preoperative delirium which equaled to 23.0%. Factors associated with preoperative delirium were cognitive impairment, Alzheimer’s dementia, dyslipidemia, respiratory tract disease, history of previous delirium, a length of hospital stay before surgery of more than 48 hours and a TMSE score lower than 23. Preoperative delirium was associated with postoperative pulmonary complications and longer hospital stay.

Conclusion: The prevalence of preoperative delirium in hip fracture elderly patients was 23.0%. Many preoperative clinical factors and postoperative adverse outcomes were associated with preoperative delirium. Therefore, routine screening for delirium in elderly with hip fracture before the surgery may provide a benefit on the clinical outcome.

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References

Sadock BJ. Kaplan and sadock's synopsis of psychiatry: behavioral sciences/clinical psychiatry. 8thed. Philadelphia:Wolters Kluwer; 2015.

Maldonado JR. Acute brain failure: pathophysiology, disgnosis, management, and sequelae of delirium. Critical Care Clinics 2017;33:461-519. https://doi.org/10.1016/j.ccc.2017.03.013

Vasunilashorn SM, Fong TG, Albuquerque A, Marcantonio ER, Schmitt EM, Tommet D, et al. Delirium severity post-surgery and its relationship with long-term cognitive decline in a cohort of patients without dementia. J Alzheimers Dis 2018; 61:347-58. https://doi.org/10.3233/JAD-170288

Adunsky A , Levy R, Heim M, Mizrahi E, Arad M. The unfavorable nature of preoperative delirium in eldery hip fractured patients. Arch Geronto Geriatr 2003;36:67-74.

https://doi.org/10.1016/S0167-4943(02)00058-4

Daniels AH, Daiello LA, Lareau CR, Robidoux KA, Luo W, Ott B, et al. Preoperative cognitive impairment and psychological distress in hospitalized eldery hip fracture patients. Am J Orthop (Belle Mead NJ) 2014:43:E46-52.

Tay E. Hip frctures in the eldery: operative versus nonoperative management. Singapore Med J 2016;57:178-81. https://doi.org/10.11622/smedj.2016071

Harris MJ, Brovman EY, Urman RD. Clinical predictor of postoperative delirium, functional status,and mortality in geriatric patients undergoing non elective surgery for hip fracture. J Cin Anesth 2019;58:61-71. https://doi.org/10.1016/j.jclinane.2019.05.010

Zakriya KJ, Christmas C, Wenz JF Sr, Franckowiak S, Anderson R, Sieber FE. Preopertive factors associated with postoperative change in confusion assessment method score in hip fracture patients. Anesth Analg 2002;94:1628-32. https://doi.org/10.1213/00000539-200206000-00050

Agrawal S, Turk R, Burton BN, Ingrande J, Gabriel RA. The association of preoperative delirium with postoperative outcomes following hip surgery in the eldery. J Clin Anesth 2020;60:28-33.

https://doi.org/10.1016/j.jclinane.2019.08.015

Juliebo V, Bjøro K, Krogseth M, Skovlund E, Ranhoff AH, Wyller TB. Risk factors for preoperative and post operative delirium in eldery patients with hip fracture. Am Geriatr Soc 2009;57:1354-61.

https://doi.org/10.1111/j.1532-5415.2009.02377.x

Wongpakaran N, Wongpakaran T, Bookamana P. Pinyopornpanish M, Maneeton B, Lerttrakarnnon P, et al. Diagnosing delirium in elderly Thai patients: Utilization of the CAM algorithm. BMC Fam Pract 2011;12:65. https://doi.org/10.1186/1471-2296-12-65

American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Washington, D.C.: American Psychiatric Association;2013. https://doi.org/10.1176/appi.books.9780890425596

Freter S, Dunbar M, Koller K, MacKnight C, Rockwood K. Prevalence and characteristics of preoperative delirium in hip fracture patients. Gerontology 2016;62:396-400. https://doi.org/10.1159/000442385

Edlund A, Lundström M, Brännström B, Bucht G, Gustafson Y. Delirium before and after operation for femoral neck fracture. J Am Geriatr Soc 2001;49:1335-40. https://doi.org/10.1046/j.1532-5415.2001.49261.x

Sukhanonsawat S, Thipakorn Y, Thisayakorn P. Incidence of delirium in hip fracture surgery at King Chulalongkorn Memorial Hospital. Chula Med J 2022;65:197-204.

Thisayakorn P, Tangwongchai S, Tantavisut S, Thipakorn Y, Sukhanonsawat S, Wongwarawipat T, et al. Immune, blood cell, and blood gas biomarkers of delirium in elderly individuals with hip fracture surgery. Dement Geriatr Cogn Disord 2021;50:161-9. https://doi.org/10.1159/000517510

Dai CQ, Wang LH, Zhu YQ, Xu GH, Shan JB, Huang WC, et al. Risk factors of perioperative blood transfusion in elderly patients with femoral intertrochanteric fracture. Medicine 2020;99:e19726

https://doi.org/10.1097/MD.0000000000019726

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Published

2023-07-10

How to Cite

1.
Sitthisarunkul W, Thipakorn Y, Thisayakorn P. Prevalence of preoperative delirium and associated factors in elderly hip fracture patients at King Chulalongkorn Memorial Hospital. Chula Med J [Internet]. 2023 Jul. 10 [cited 2024 May 20];67(1). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/43