Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios in acute hospitalized patients with schizophrenia

Apichan  Dangrungroj; Mayteewat  Chiddaycha

Authors

Apichan Dangrungroj Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
Mayteewat Chiddaycha Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

Keywords:

Neuroinflammation, neutrophil-to-lymphocyte ratio, NLR, schizophrenia

Abstract

Background: Schizophrenia has increasingly been linked to inflammation. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have emerged as potential indicators of systemic inflammation.

Objectives: The objectives of this study were to compare the NLR, MLR, and PLR between patients with schizophrenia and healthy controls and to investigate the factors associated with NLR.

Methods: This retrospective study included 102 sex- and age-matched patients hospitalized with schizophrenia and 102 healthy control subjects. The NLR, MLR, and PLR were calculated from the complete blood count results and compared between the groups. Sociodemographic data and clinical characteristics were analyzed using multiple linear regression to identify factors associated with the NLR in patients with schizophrenia.

Results: The NLR and MLR of patients with acute schizophrenia were found to be significantly higher compared to those of the control group (3.0 ± 2.0 vs. 1.8 ± 0.8, P < 0.01; 0.3 ± 0.1 vs. 0.2 ± 0.1, P < 0.01, respectively). However, the PLR was not significantly different between the two groups (152.1 ± 70.8 vs. 143.1 ± 49.1, P = 0.29). First-episode illness was the only identified factor associated with a higher NLR in patients with schizophrenia (P < 0.05).

Conclusion: The higher NLR and MLR values found in hospitalized patients with schizophrenia support the inflammatory hypothesis of schizophrenia.

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