Effectiveness of vitamin D3 in facilitating the therapeutic progression of healing diabetic foot ulcers

Fatemeh  Nouri; Sara  Aghaei; Gülüzar  Özbolat; Yusuf  Döğüş; Mahdi  Mirhamidi; Mahmoud  Reza Rahimi Barghani; Amin  Daemi

Authors

Fatemeh Nouri Science and Research Branch, Islamic Azad University (SRBIAU), Tehran, Iran
Sara Aghaei Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Gülüzar Özbolat Faculty of Health Science, Sinop University, Sinop, Turkey
Yusuf Döğüş Faculty of Medicine, Cukurova University, Adana, Turkey
Mahdi Mirhamidi Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Mahmoud Reza Rahimi Barghani Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Amin Daemi Faculty of Medicine, Cukurova University, Adana, Turkey

Keywords:

Metabolic status, vitamin D, vitamin D supplementation, wound healing

Abstract

Background: Diabetes and its complications afflict a large portion of the population worldwide, and it is estimated that its prevalence in all age groups will increase from 2.8% in 2000 to 4.4% in 2030. Moreover, it is well known that vitamin D may cause rapid wound healing and exert anti-inflammatory effects.

Objective: This study aimed to investigate the efficacy of vitamin D3 on the healing of chronic diabetic foot ulcers to improve the quality of life of patients with diabetes. The present research is conducted as a randomized controlled trial.

Methods: Forty patients were randomly divided into an experimental group (vitamin D supplementation) and a control group (placebo) using a sampling method based on the inclusion criteria. The patients were evaluated for ulcer debridement every two weeks (0 (T0), 2 (T1), 4 (T2), 6 (T3), 8 (T4), 10 (T5), and 12 (T6)) after the intervention. The collected data were analyzed using SPSS-23 software.

Results: The experimental group exhibited significantly decreased ulcer length (−1.6 ± 0.8 cmvs.−0.5 ± 1.4 cm, P = 0.005), ulcer width (−1.7 ± 1.2 cmvs.−0.9 ± 1.2 cm,P = 0.025), and ulcer depth (−0.6 ± 0.5 cmvs.−0.3 ± 0.4 cm, P = 0.025) after 12 weeks of intervention compared to those of the control group. These results reveal that vitamin D had a significant relationship with all stages of the wound-healing process (P < 0.01).

Conclusions: In patients with chronic diabetic foot ulcers, the use of vitamin D supplementation can improve wound healing. Moreover, vitamin D had a significant relationship with all stages of the wound-healing process except re-epithelialization and angiogenesis.

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