Correlation of clinical and imaging findings in difference stage of neurocysticercosis

Authors

  • Surachat Sittiyot Faculty of Medicine, Chulalongkorn University,King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
  • Wiyada Supadun Faculty of Medicine, Chulalongkorn University,King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand

Keywords:

Neurocysticercosis, stage, seizure

Abstract

Background: The common clinical manifestations of neurocysticercosis (NCC) was determined by several important factors. There is no previous study showing a correlation between difference stage of NCC and clinical presentation. The propose of this study was to determine correlation between different stages of NCC and its clinical presentation.

Methods: A retrospective descriptive study was performed using medical records and picture archiving and communication system from October 14, 2004 to October 18, 2019 in patients who definite diagnosed NCC from computerized tomography (CT) or magnetic resonance imaging (MRI) of brain. Neuroimaging was reviewed by two observers. The correlation between stage of NCC and clinical presentation was analyzed independently using Chi-square test and regression analysis.

Results: Statistical analysis was performed on 28 patients; Vesicular stage was seen in 8 (28.6%) patients, colloidal vesicular stage was seen in 8 (28.6%) patients, granular nodular stage was seen in 10 (35.7%) patients, nodular calcified stage was seen in 11 (39.3%) patients. Most patients, the lesions were located in the cerebral hemisphere 25 (89.3%) patients. Perileisonal edema was seen in 16 (57.1%) patients. There was no correlation between different stage of NCC and clinical presentation. But the location of NCC on cerebral hemisphere, perilesional edema and onset of clinical presentation were significant on seizure group (P = 0.026, P = 0.010 and P = 0.018, respectively). Location in cerebral hemisphere, perileisonal edema and onset of clinical presentation were imaging and clinical variables that was associated with seizure group on univariate analysis regression. However, on multivariate binary logistic regression, location in cerebral hemisphere, perilesional edema and onset of clinical presentation were not the factor to be independently associated with seizure group.

Conclusion: There is no correlation between different stages of NCC and its clinical presentations.

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References

Duque KR, Escalaya AL, Zapata W, Burneo JG, Bustos JA, Gonzales I, et al. Clinical topography relation ship in patients with parenchymal neurocysticercosis and seizure. Epilepsy Res 2018;145:145-52. https://doi.org/10.1016/j.eplepsyres.2018.06.011

Garcia HH, Hector H Garcia 1, Nash TE, Del Brutto OH. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 2014;13:1202-15. https://doi.org/10.1016/S1474-4422(14)70094-8

Anantaphruti MT, Waikagul J, Yamasaki H, Ito A. Cysticercosis and taeniasis in Thailand. Southeast Asain J Trop Med Public Health 2007;38:151-8.

Kulkantrakorn K. Neurocysticercosis: Revisited. J Infect Dis Antimicrob Agents 2005;22:27- 38.

Del Brutto OH, Nash TE, White AC Jr , Rajshekhar V, Wilkins PP, Singh G, et al. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci 2017;372:202-10. https://doi.org/10.1016/j.jns.2016.11.045

Osborn AG, Salzman KL, Jhaveri MD. Diagnostic imaging: brain, 3rd. edition, Philadeiphia: Elsevier;2016.

Zhao JL, Lerner A, Shu Z, Gao XJ, Zee CS. Imaging spectrum of neurocysticercosis. Radiol Infect Dis 2015;1:94-102.

https://doi.org/10.1016/j.jrid.2014.12.001

Estrada SS, Verzelli LF, Montilva SS, Acosta CA, Caňellas AR. Imaging findings in neurocysticercosis. Radiologia 2013;55:130-41.

https://doi.org/10.1016/j.rxeng.2011.11.003

Carabin H, Ndimubanzi PC, Budke CM, Nguyen H, Qian Y, Cowan L, et al. Clinical manifestations associated with neurocysticercosis: a systematic review. PLoS Negl Trop Dis 2011;5:e1152. https://doi.org/10.1371/journal.pntd.0001152

Kelvin EA Carpio A, Bagiella E, Leslie D, Leon P, Andrews H, et al. The association of host age and gender with inflammation around neurocysticercosis cysts. Ann Trop Med Parasitol 2009;103:487-99. https://doi.org/10.1179/000349809X12459740922291

Nash T. Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment. Pathog Glob Healthy 2012;106:275-9. https://doi.org/10.1179/2047773212Y.0000000026

Marin B, Preux P. Perilesional brain oedema in calcific neurocysticercosis: a target to prevent seizure recurrence?. Lancet Neurol 2008;7:1075-6. https://doi.org/10.1016/S1474-4422(08)70244-8

Gupta RK, Awasthi R, Rathore RKS, Verma A, Sahoo P, Paliwal VK, et al. Understanding epileptogenesis in calcified neurocysticercosis with perfusion MRI. Neurology 2012;78:618-25. https://doi.org/10.1212/WNL.0b013e318248deae

Del Brutto OH, Santibanez R, Noboa CA, Aguirre R, Diaz E, Alarcon TA. Epilepsy due to neurocysticercosis: Analysis of 203 patients. Neurology 1992;42:389-92. https://doi.org/10.1212/WNL.42.2.389

Nash TE, Del Brutto OH, Butman JA, Corona T, Delgado-Escueta A, Duron RM, et al. Calcific neurocysticercosis and epileptogenesis. Neurology 2004;62:1934-8. https://doi.org/10.1212/01.WNL.0000129481.12067.06

Nash T, Pretell E, Lescano A, Bustos J, Gilman R, Gonzalez A, et al. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. Lancet Neurology 2008;7:1099-105.

https://doi.org/10.1016/S1474-4422(08)70243-6

Singh AK, Garg RK, Rizvi I, Malhotra HS, Kumar N, Gupta RK. Clinical and neuroimaging predictors of seizure recurrence in solitary calcified neurocysticercosis:A prospective observational study. Epilepsy Res 2017;137:78-83.

https://doi.org/10.1016/j.eplepsyres.2017.09.010

Carpio A, Escobar A, Hauser WA. Cysticercosis and epilepsy: a critical review. Epilepsia 1998;39:1025-40.

https://doi.org/10.1111/j.1528-1157.1998.tb01287.x

Leite JP, Terra-Bustamante VC, Fernandes RM, Santos AC, Chimelli L, Sakamoto AC, et al. Calcified neurocysticercotic lesions and postsurgery seizure control in temporal lobe epilepsy. Neurology 2000;55: 1485-91. https://doi.org/10.1212/WNL.55.10.1485

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Published

2023-07-18

How to Cite

1.
Sittiyot S, Supadun W. Correlation of clinical and imaging findings in difference stage of neurocysticercosis. Chula Med J [Internet]. 2023 Jul. 18 [cited 2024 Nov. 6];66(3). Available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/92