A A case study of pseudocholinesterase deficiency

Main Article Content

Suchawadee Boonswang

Abstract

Pseudocholinesterase deficiency is an uncommon anesthetic problem relevant to standard anesthetic drugs that once occurred it requires systematic approach and step-by-step management, it also implicates in patients’ and his/her relatives’ future operation. The purpose of this study is to demonstrate clinical presentation, comprehensive management steps, and knowledge of this pathology.


 

Article Details

Section
Case Report

References

Acharya S, Bhattarai S, Shrimanker I, Gupta SS. A prolonged paralysis with succinylcholine in pseudocholinesterase deficiency: an undesired effect. QJM. 2022 Aug 13;115(8):547-548. doi: 10.1093/qjmed/hcac103. PMID: 35426937.

Hemadri M, Purva M, Traykova V. Unexpected prolonged neuromuscular block after mivacurium: a case report. Med Princ Pract. 2002 Jan-Mar;11(1):50-2. doi: 10.1159/000048662. PMID: 12116697.

Andersson ML, Møller AM, Wildgaard K. Butyrylcholinesterase deficiency and its clinical importance in anaesthesia: a systematic review. Anaesthesia. 2019 Apr;74(4):518-528. doi: 10.1111/anae.14545. Epub 2019 Jan 1. PMID: 30600548.

Robles A, Michael M, McCallum R. Pseudocholinesterase Deficiency: What the Proceduralist Needs to Know. Am J Med Sci. 2019 Mar;357(3):263-267. doi: 10.1016/j.amjms.2018.11.002. Epub 2018 Nov 10. PMID: 30578021.

Cornelius BW, Jacobs TM. Pseudocholinesterase Deficiency Considerations: A Case Study. Anesth Prog. 2020 Sep 1;67(3):177-184. doi: 10.2344/anpr-67-03-16. PMID: 32992329; PMCID: PMC7530809.

Delacour H, Lushchekina S, Mabboux I, Bousquet A, Ceppa F, Schopfer LM, Lockridge O, Masson P. Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium. PLoS One. 2014 Jul 23;9(7):e101552. doi: 10.1371/journal.pone.0101552. PMID: 25054547; PMCID: PMC4108472.

Tokunaga N, Shima H, Okamoto T, Maekawa M, Minakuchi J. The First-Known Case of Hereditary Heterozygous Butyrylcholinesterase Deficiency in a Patient on Dialysis. Cureus. 2024 Jan 29;16(1):e53153. doi: 10.7759/cureus.53153. PMID: 38420074; PMCID: PMC10900173.

Mohammad FK, Mohammed AA, Garmavy HM, Rashid HM. Association of Reduced Maternal Plasma Cholinesterase Activity With Preeclampsia: A Meta-Analysis. Cureus. 2023 Oct 17;15(10):e47220. doi: 10.7759/cureus.47220. PMID: 38022101; PMCID: PMC10653552.

Lurati AR. Organophosphate exposure with pseudocholinesterase deficiency. Workplace Health Saf. 2013 Jun;61(6):243-5. doi: 10.1177/216507991306100602. PMID: 23738571.

Soliday FK, Conley YP, Henker R. Pseudocholinesterase deficiency: a comprehensive review of genetic, acquired, and drug influences. AANA J. 2010 Aug;78(4):313-20. PMID: 20879632.

Zencirci B. Sertraline-induced pseudocholinesterase enzyme deficiency. Int J Gen Med. 2010 Nov 16;3:375-8. doi: 10.2147/IJGM.S14365. PMID: 21189834; PMCID: PMC3008290.

Kurnutala LN, Rugnath N. Pseudocholinesterase Deficiency - Is Succinylcholine Still Needed to Facilitate Endotracheal Intubation? Cureus. 2020 Sep 29;12(9):e10721. doi: 10.7759/cureus.10721. PMID: 33150117; PMCID: PMC7603876.

Thomsen JL, Nielsen CV, Eskildsen KZ, Demant MN, Gätke MR. Awareness during emergence from anaesthesia: significance of neuromuscular monitoring in patients with butyrylcholinesterase deficiency. Br J Anaesth. 2015 Jul;115 Suppl 1:i78-i88. doi: 10.1093/bja/aev096. PMID: 26174305.

Maiorana A, Roach RB Jr. Heterozygous pseudocholinesterase deficiency: a case report and review of the literature. J Oral Maxillofac Surg. 2003 Jul;61(7):845-7. doi: 10.1016/s0278-2391(03)00163-0. PMID: 12856264.

Trujillo R, West WP. Pseudocholinesterase Deficiency. 2023 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082076.