PROPORTION AND FACTORS ASSOCIATED WITH RAPID KIDNEY FUNCTION DECLINE (RKFD) IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A RETROSPECTIVE STUDY

Authors

  • Surawach Krasairtechahirun Chonnabot Hospital, KhonKaen Province
  • Kamthorn Dana Srimahasarakham Nursing College, Faculty of Nursing, Praboromarajchanok Institute
  • Anucha Taiwong Srimahasarakham Nursing College, Faculty of Nursing, Praboromarajchanok Institute
  • Busakorn Kunork Chonnabot Hospital, KhonKaen Province
  • Piyawan Larangsit Chonnabot Hospital, KhonKaen Province

Keywords:

Rapid kidney function decline (RKFD), Chronic kidney disease patients, Factors

Abstract

This analytical study aimed to determine the proportion of rapid kidney function decline and the factors associated with the rapid decline of patients with chronic kidney disease in a Chonnabot District, Khon Kaen province. Data from 202 patients in medical records were reviewed and analyzed using descriptive statistics, including frequency, percentage, mean, and inferential statistics, including odds ratio and 95% confidence interval.
The study found that 39 patients out of the 202 samples had a rapid kidney function decline, accounting for 19.31 percent (95% CI 14.43-25.33). Factors associated with rapid kidney function decline included low body mass index (BMI < 18.5) (ORadj 2.44; 95%CI 1.91-6.54), alcohol consumption (ORadj 2.21; 95%CI 1.69-7.05), high uric acid levels (ORadj 4.52; 95%CI 1.46-13.96), high cholesterol levels (ORadj 3.59; 95%CI 1.09-11.86), and high LDL levels (ORadj 1.25; 95%CI 1.07-3.87).

Downloads

Download data is not yet available.

References

Cha’on U, Tippayawat P, Sae-ung N, et al. High prevalence of chronic kidney disease and its related risk factors in rural areas of Northeast Thailand. Sci Rep 2022; 12: 18188.

Tangri N, Peach EJ, Franzén S, Barone S, Kushner PR. Patient Management and Clinical Outcomes Associated with a Recorded Diagnosis of Stage 3 Chronic Kidney Disease: The REVEAL-CKD Study. Adv Ther 2023; 40(6): 2869-2885. doi: 10.1007/s12325-023-02482-5.

Nie S, Shiyu Z, Claudia C, Shan C, Mengyun J, Shiyu Z, et al. Characteristics of patients with undiagnosed stage 3 chronic kidney disease: results from an observational study (REVEAL-CKD) in China. The Lancet Regional Health Western Pacific 2025; 54: 101275.

Chanchairujira T, Kanjanabuch T, Pongskul C, Sumethkul V, Supaporn T. Dialysis and kidney transplant practices and challenges in Thailand. Nephrology 2023; 28 (Suppl. 1): 8-13.

Wong G, Bernier-Jean A, Rovin B, Ronco P, Editors of Kidney International. Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality. Kidney international 2024; 105(6): 1144–1146.

Lee WV, Song Y, Chun JS, Ko M, Jang HY, Kim IW, et al. Development of a machine learning model for precision prognosis of rapid kidney function decline in people with diabetes and chronic kidney disease. Diabetes research and clinical practice 2024; 217: 111897.

Dutra MC, Uliano EJ, Machado DF, Martins T, Schuelter-Trevisol F, Trevisol DJ. Assessment of kidney function in the elderly: a population-based study. J Bras Nefrol 2014; 36(3): 297-303. doi: 10.5935/0101-2800.20140043. PMID: 25317611.

Wang M, Sun X, Zhang W, Zhang Q, Qian J, Chen W, et al. Frailty and the risk of kidney function decline in the elderly population: The Rugao Longevity and Ageing Study. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association 2021; 36(12): 2274–2281.

Suresh K, Charan N, Moneshaa SS. Cardiovascular morbidity and dyslipidemia in chronic kidney disease: a cross-sectional study. International Journal of Advances in Medicine 2018; 5(2): 245-248.

Xing J, Huang L, Ren W, Mei X. Risk factors for rapid kidney function decline in diabetes patients. Renal failure 2024; 46(2): 2398188.

Theeranut A, Methakanjanasak N, Lertsinudom S, Surit P, Panyaek N, Leeladapattarakul S, et al. Integrated Care Model by the Village Health Volunteers to Prevent and Slow Down Progression of Chronic Kidney Disease in a Rural Community, Thailand. Journal of primary care & community health 2024; 15: 1-11.

Boontakanon J. Factors associated with Rapid decline of Renal function in Patients with CKD stage 3-4 at Kasetsomboon Hospital, Chaiyaphum. Regional Health Promotion Center 9 Journal 2023; 17(1): 13-27. [in Thai].

Abramson JH, WinPepi updated: Computer programs for epidemiologists and their teaching potential. Epidemiologic Perspectives & Innovations 2011; 8(1): 1-9.

Yoshida Y, Kashiwabara K, Hirakawa Y, Tanaka T, Noso S, Ikegami H, et al. Conditions, pathogenesis, and progression of diabetic kidney disease and early decliner in Japan. BMJ open diabetes research & care 2020; 8(1): e000902.

Hawthorne G, Lightfoot CJ, Smith AC, Khunti K, Wilkinson TJ. Multimorbidity prevalence and patterns in chronic kidney disease: findings from an observational multicentre UK cohort study. International urology and nephrology 2023; 55(8): 2047–2057.

Singh K, Kondal D, Jagannathan R, Ali MK, Prabhakaran D, Narayan KM. et al. Rate and risk factors of kidney function decline among South Asians with type 2 diabetes: analysis of the CARRS Trial. BMJ open diabetes research & care 2024; 12(4): e004218.

Chanpitakkul M, Praveen D, John R, Ghosh A, Lekagul S, Kaewhiran M, et al. Rationale, Design, and Intervention Development of a Mobile Health-Led Primary Care Program for Management of Type 2 Diabetes in Rural Thailand: Protocol for a SMARThealth Diabetes Study. JMIR research protocols 2024; 13: e59266.

Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, et al. Causal effect of alcohol use on the risk of end-stage kidney disease and related comorbidities: a Mendelian randomization study. Kidney research and clinical practice 2021; 40(2): 282–293.

Cimmino G, Natale F, Franzese R, Morello M, Titolo G, Mollo N, et al. Uric acid in atherosclerosis and cardiovascular diseases: innocent bystander or ruthless killer?. Explor Musculoskeletal Dis 2024; 2(3): 189 -207.

Dana K, Suriyo S, Kumsiriruk N. A systematic review: Family support to glycemic control among type II diabetes mellitus patients. Community Health Development Quarterly Khon Kaen University 2023; 11(2): 235-249. [in Thai].

Downloads

Published

2025-03-24

How to Cite

Krasairtechahirun, S., Dana, K., Taiwong, A., Kunork, B., & Larangsit, P. (2025). PROPORTION AND FACTORS ASSOCIATED WITH RAPID KIDNEY FUNCTION DECLINE (RKFD) IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A RETROSPECTIVE STUDY. Community Health Development Quarterly Khon Kaen University, 13(1), 63–77. retrieved from https://he05.tci-thaijo.org/index.php/CHDMD_KKU/article/view/6592

Issue

Section

Original Article