Characteristics and physical outcomes of kratom users at a substance abuse treatment center
Keywords:
Kratom, behavior, physical outcomeAbstract
Background: Despite many disadvantages such as physical and mental disorders, family disruption, crime, etc., substance use disorder is continuously reported worldwide. Twenty - nine million people were reported to suffer from substance abuse. In addition, the survey found that only 1/6 of substance abusers throughout the world were able to access medical services. Kratom (Mitragyna speciosa Korth) has been used not only as medicine, but also as psychedelic drug for a long time.
Objective: To study behavioral and physical consequences of kratom use.
Methods: One hundred and six kratom users were recruited into this study at the Princess Mother National Institute on Drug Abuse Treatment (PMNIDAT). Collected data included 1) general information, 2) kratom use profile, 3) side effects from using kratom, 4) Naranjo’s algorithm, and 5) Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) Section H. Statistics used to analyze these data were percentage, mean, standard deviation, independent t-test, Chi-square test, and Pearson’s correlation.
Results: Kratom use was classified as either boiling (55.6%) or chewing (41.7%). A number of kratom users often took other substances. Although the boiling-pattern group took more other drugs, the chewing-pattern group significantly had more headaches, arthritis, nausea, or constipation when compared to the other.
Conclusion: Kratom substance users frequently use other substances. There are multiple adverse effects from both patterns of kratom use.
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References
Asanakornchai S, Saingam D, Siriwong A, Wungsintaweekul J. Conclusion of Kratom plant. Bangkok: Charansanitwong Publisher; 2558.
Executive Committee, Network of Substance Abuse Organizations. Substance abuse analysis 2002 - 2012. Bangkok: Charansanitwong Publisher; 2556.
Kumarnsit E. In summary, the Kratom plant symposium during 17-18 October 2005, Kratom conference at the Convention Room, Hall floor. Conference Center, Chulabhorn Research Institute. Bangkok: Chulabhorn Research Institute; 2005.
Vuttamavet V. Thai Traditional Pharmacy and herbal properties. 2nd ed. Bangkok: Siam Packaging and Printing Publisher; 2009.
Deeviset K. Thai traditional pharmacy. Bangkok: The War Veterans Organization Publisher; 1999.
Prasatvet P. Medical knowledge and literary heritage of the nation. Bangkok: The Teachers' Council of Thailand of Lat Phrao Publisher; 1999.
Keawpradub N. Alhaloids from the fresh leaves of Mitragya speciosa (Korth) Havil. Bangkok: Chulalongkorn University; 1990.
Cheaha D, Sawangjaroen K, Shuprisha A, Kumarnsit E. Effects of the extract from Kratom (Mitragyna specioca) leaves on alcohol-induced dependent animals. Thaksin University J 2554;14:211-19.
Junsirimongkol B, Singkhorn O, Thipnuruk B, Puanglod D. The study of symptoms of clinical effects in Kratom abusers at the Outpatient Clinic, Suansaranrom Hospital. J Somdet Chaopraya Institute of Psychiatry 2009;3:41-52.
Verachai V, Nilbun S. Clinical symptoms of kratom dependence. Bull Dept Med Serv 2005; 30:310-3.
Chansirimongkol B, Laopiyasakul R, Tipmontian V, Rhungbumrung K, Yimyeab S.. The health status of Kratom users, Phunphin District, Surat Thani. Songklanagarind Med J 2549;24:549-50.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
https://doi.org/10.1038/clpt.1981.154
Suwannakesawong W, Sriphiromya P, Tragulpiankit P, Phetcharat C, Sornsrivichai V. Evaluation of Thai algorithm usage for adverse drug reaction monitoring. J Health Sci 2016;25:673-82.
Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A, Farrer L, Kranzier HR. Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug Alcohol Depend 2005;80:303-12. https://doi.org/10.1016/j.drugalcdep.2005.04.005
Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, et al. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addict Behav 2011;36:156-60. https://doi.org/10.1016/j.addbeh.2010.08.031
Warner ML, Kaufman NC, Grundmann O. The pharmacology and toxicology of kratom: from traditional herb to drug of abuse. Int J Legal Med 2016;130:127-38.
https://doi.org/10.1007/s00414-015-1279-y
Thongpraditchot S. Pharmacological effects of mitragynine : an active ingredient in Mitragyna speciosa. Medicinal Plant Newsletter. 2006;24:6-16.
Chittrakarn S, Sawangjaroen K, Prasettho S, Janchawee B, Keawpradub N. Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract. J Ethnopharmacol 2008; 116:173-8. https://doi.org/10.1016/j.jep.2007.11.032
Kumarnsit E, Keawpradub N, Nuankaew W. Acute and long-term effects of alkaloidextract of Mitragyna speciosa on food and water intake and body weight in rats. Fitoterapia 2006;77: 339-45.
https://doi.org/10.1016/j.fitote.2006.04.006
Tsuchiya S, Miyashita S, Yamamoto M, Horie S, Sakai S, Aimi N, et al. Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized rats. Eur J Pharmacol 2002;443:185-8. https://doi.org/10.1016/S0014-2999(02)01588-1
Watanabe K, Yano S, Horie S, Yamamoto LT. Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea- pig ileum through the opioid receptor. Life Sci 1997;60:933-42.
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