Addressing the burden of premature birth and its prevention in developing countries: is it time to act now?

Authors

  • Mahaveer Singh Lakra Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India
  • Amar Taksande Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India
  • Revat J. Meshram Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India
  • Ashwini Lakra Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India
  • Amit Kumar All India Institute of Medical Sciences, Nagpur, India
  • Deepak Gandhi Medeor Hospital, Dubai
  • Roshan Prasad Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India
  • Mayur Wanjari Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, India

Keywords:

Antenatal care, health program, neonatal death, respiratory distress syndrome, prematurity

Abstract

India accounts for approximately 3.5 million preterm births annally, representing about 25% of the global burden. Premature birth poses a substantial burden, with an especially profound impact on families and health systems in low-and middle-income countries, where access to adequate healthcare is limited. Premature birth remains a leading cause of neonatal death among children under the age of five years due to organ immaturity, sepsis, and respiratory distress syndrome. Efforts to reduce premature birth include improving access to quality prenatal care, enhancing neonatal care services, and implementing targeted public health interventions. Despite ongoing challenges, considerable progress has been made through concerted efforts by governments, international organizations, healthcare providers, and community stakeholders. Continued investment, monitoring, and innovation are crucial to further prevent preterm births and improve the outcomes. Such efforts aim to alleviate the burden on families and caregivers while strengthening already strained health systems worldwide.

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References

Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB, et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health 2013;10 Suppl 1:S2.

https://doi.org/10.1186/1742-4755-10-S1-S2

Morniroli D, Tiraferri V, Maiocco G, De Rose DU, Cresi F, Coscia A, et al. Beyond survival: the lasting effects of premature birth. Front Pediatr 2023;11:1213243.

https://doi.org/10.3389/fped.2023.1213243

Ohuma EO, Moller AB, Bradley E, Chakwera S, Hussain-Alkhateeb L, Lewin A, et al. National, regional, and worldwide estimates of preterm birth in 2020, with trends from 2010: a systematic analysis. Lancet 2023;402:1261-71.

https://doi.org/10.1016/S0140-6736(23)00878-4

Sankar MJ, Neogi SB, Sharma J, Chauhan M, Srivastava R, Prabhakar PK, et al. State of newborn health in India. J Perinatol 2016;36:S3-S8.

https://doi.org/10.1038/jp.2016.183

ACOG technical bulletin. Preterm labor. Number 206- June 1995 (Replaces No. 133, October 1989). Int J Gynaecol Obstet 1995;50:303-13.

https://doi.org/10.1016/0020-7292(95)90274-0

Muhe LM, McClure EM, Nigussie AK, Mekasha A, Worku B, Worku A, et al. Major causes of death in preterm infants in selected hospitals in Ethiopia (SIP): a prospective, cross-sectional, observational study. Lancet Glob Health 2019;7:e1130-8.

https://doi.org/10.1016/S2214-109X(19)30220-7

Patel RM: Short- and long-term outcomes for extremely preterm infants. Am J Perinatol 2016;33:318-28.

https://doi.org/10.1055/s-0035-1571202

Hebballi NB, Avritscher EB, Garcia E, Bain A, BartzKurycki MA, Tsao K, et al. Healthcare utilization among infants discharged from the neonatal intensive care unit: a descriptive cost analysis. Health Serv Insights 2023;16:11786329231169604.

https://doi.org/10.1177/11786329231169604

Rolnitsky A, Unger SL, Urbach DR, Bell CM. Cost of neonatal intensive care for extremely preterm infants in Canada. Transl Pediatr 2021;10:1630-6.

https://doi.org/10.21037/tp-21-36

Leon Hernandez A. The impact of prematurity on social and emotional development. Clin Perinatol 2018;45: 547-55.

https://doi.org/10.1016/j.clp.2018.05.010

Khandre V, Potdar J, Keerti A. Preterm birth: an overview. Cureus 2022;14:e33006.

https://doi.org/10.7759/cureus.33006

ACOG committee opinion no. 561: nonmedically indicated early-term deliveries. Obstet Gynecol 2013;121:911-5.

https://doi.org/10.1097/01.AOG.0000428649.57622.a7

Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008;371:75-84.

https://doi.org/10.1016/S0140-6736(08)60074-4

Lakra MS, Lakhkar B, Karotkar SA, Meshram RRJ. A case report of an unusual and rare social cause of extreme prematurity in a newborn. J Datta Meghe Institute Med Sci Univ 2023;18:93-6.

https://doi.org/10.4103/jdmimsu.jdmimsu_489_22

Tana M, Tirone C, Aurilia C, Lio A, Paladini A, Fattore S, et al. Respiratory management of the preterm infant: supporting evidence-based practice at the bedside. Children (Basel) 2023;10:535.

https://doi.org/10.3390/children10030535

Sivanandan S, Sankar MJ. Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis. BMJ Glob Health 2023;8:e010728.

https://doi.org/10.1136/bmjgh-2022-010728

Schulzke SM, Stoecklin B. Update on ventilatory management of extremely preterm infants-a neonatal intensive care unit perspective. Paediatr Anaesth 2022;32:363-71.

https://doi.org/10.1111/pan.14369

Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF. Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol 2018;63:618-37.

https://doi.org/10.1016/j.survophthal.2018.04.002

Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ. Cognitive and behavioral outcomes of school-aged children who were born preterm: a metaanalysis. JAMA 2002;14:728-37.

https://doi.org/10.1001/jama.288.6.728

van Zijl MD, Koullali B, Mol BW, Pajkrt E, Oudijk MA. Prevention of preterm delivery: current challenges and future prospects. Int J Womens Health 2016;8:633-45.

https://doi.org/10.2147/IJWH.S89317

Chang HH, Larson J, Blencowe H, Spong CY, Howson CP, Cairns-Smith S, et al. Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index. Lancet 2013;381:223-34.

https://doi.org/10.1016/S0140-6736(12)61856-X

Newnham JP, Dickinson JE, Hart RJ, Pennell CE, Arrese CA, Keelan JA. Strategies to prevent preterm birth. Front Immunol 2014;5:584.

https://doi.org/10.3389/fimmu.2014.00584

Séassau A, Munos P, Gire C, Tosello B, Carchon I. Neonatal care unit interventions on preterm development. Children 2023;10:999.

https://doi.org/10.3390/children10060999

Wang HH, Hwang YS, Ho CH, Lai MC, Chen YC, Tsai WH. Prevalence and initial diagnosis of cerebral palsy in preterm and term-born children in Taiwan: a nationwide, population-based cohort study. Int J Environ Res Public Health 2021;18:8984.

https://doi.org/10.3390/ijerph18178984

Kidokoro H, Anderson PJ, Doyle LW, Woodward LJ, Neil JJ, Inder TE. Brain injury and altered brain growth in preterm infants: predictors and prognosis. Pediatrics 2014;134:e444-53.

https://doi.org/10.1542/peds.2013-2336

Yates N, Gunn AJ, Bennet L, Dhillon SK, Davidson JO. Preventing brain injury in the preterm infant-current controversies and potential therapies. Int J Mol Sci 2021;22:1671.

https://doi.org/10.3390/ijms22041671

O'Shea TM. Diagnosis, treatment, and prevention of cerebral palsy. Clin Obstet Gynecol 2008;51:816-28.

https://doi.org/10.1097/GRF.0b013e3181870ba7

Ryan M, Lacaze-Masmonteil T, Mohammad K. Neuroprotection from acute brain injury in preterm infants. Paediatr Child Health 2019;24:276-90.

https://doi.org/10.1093/pch/pxz056

Keelan JA, Newnham JP. Recent advances in the prevention of preterm birth. F1000Res 2017;6:F1000 Faculty Rev-1139.

https://doi.org/10.12688/f1000research.11385.1

Gülmezoglu AM, Lawrie TA, Hezelgrave N, Oladapo OT, Souza JP, Gielen M, et al. Interventions to reduce maternal and newborn morbidity and mortality. In: Black RE, Laxminarayan R, Temmerman M, Walker N, editors. Reproductive, Maternal, Newborn, and Child Health: Disease Control Priorities. vols.2. 3rd ed. Washington DC: The international bank for reconstruction and development / The world bank; 2016. p. 115-36

https://doi.org/10.1596/978-1-4648-0348-2_ch7

Theobald S, Brandes N, Gyapong M, El-Saharty S, Proctor E, Diaz T, et al. Implementation research: new imperatives and opportunities in global health. Lancet 2018;392:2214-28.

https://doi.org/10.1016/S0140-6736(18)32205-0

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Published

2025-11-28

How to Cite

1.
Singh Lakra M, Taksande A, J. Meshram R, Lakra A, Kumar A, Gandhi D, Prasad R, Wanjari M. Addressing the burden of premature birth and its prevention in developing countries: is it time to act now?. Chula Med J [internet]. 2025 Nov. 28 [cited 2025 Dec. 8];69(6). available from: https://he05.tci-thaijo.org/index.php/CMJ/article/view/7032