Functional Independency in Patient with Brain Glioblastoma in King Chulalongkorn Memorial Hospital
Keywords:
Glioblastoma multiforme, GBM, functional dependency, KPSAbstract
Background: Glioblastoma is the most common primary malignant brain tumor. Glioblastoma prognosis is poor with average life expectancy about 10-15 months. Many modalities of treatment (i.e., surgical tumor resection, chemotherapy, radiation therapy) are used for prolong the patient’s life. However longer survival may not mean better quality of life. The aim of this study is to assess and compare the quality of life and duration of Functional Independence in patient with Brain glioblastoma after tumor resection and non-resection group.
Methods: We conducted a retrospective cohort study. 87 adult patients (>18 years old) with glioblastoma WHO grade IV from pathological diagnosis who underwent surgery (tumor resection, biopsy) during 2007 – 2023 in King Chulalongkorn Memorial Hospital were included. Exclusion criteria were patient with incomplete information, spinal glioblastoma, poor pre-operative KPS. Defined functional independent was KPS >70. Patient’s medical record was reviewed for pre-operative Kanofsky score (KPS), post-operative KPS at 1 week, 1 month, 3 months, 6 months, duration which patient had functional independent, complication of surgery.
Result: The mean time from first diagnosis of brain GBM to dependence status in tumor resection group was 11.60 months and in non-tumor resection group is 3.86 months, no statistically significant (p = 0.087). The KPS in each follow-up time was not different between groups.
Conclusion: The patient with brain GBM, receiving tumor resection treatment tend to had more time in independent than patient receiving non-tumor resection treatment.
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References
Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M. Management of glioblastoma: State of the art and future directions. CA Cancer J Clin. 2020;70(4):299-312.
Rønning PA, Helseth E, Meling TR, Johannesen TB. A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme. Neuro Oncol. 2012;14(9):1178-84.
Fekete B, Werlenius K, Örndal C, Rydenhag B. Prognostic factors for glioblastoma patients—a clinical population-based study. Acta Neurol Scand. 2016;133(6):434-41.
Witthayanuwat S, Pesee M, Supaadirek C, Supakalin N, Thamronganantasakul K, Krusun S. Survival analysis of glioblastoma multiforme. Asian Pac J Cancer Prev. 2018;19(9):2613-7.
Nelson DF, Diener-West M, Horton J, Chang CH, Schoenfeld D, Nelson JS. Combined modality approach to treatment of malignant gliomas—re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: a joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group. NCI Monogr. 1988;(6):279-84.
Bleehen NM, Stenning SP. A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party. Br J Cancer. 1991;64(4):769-74.
Laws ER, Parney IF, Huang W, Anderson F, Morris AM, Asher A, et al. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg. 2003;99(3):467-73.
Korshunov A, Sycheva R, Golanov A. The prognostic relevance of molecular alterations in glioblastomas for patients age <50 years. Cancer. 2005;104(4):825- 32.
Pichlmeier U, Bink A, Schackert G, Stummer W. Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol. 2008;10(6):1025-34.
Scott JG, Suh JH, Elson P, Barnett GH, Vogelbaum MA, Peereboom DM, et al. Aggressive treatment is appropriate for glioblastoma multiforme patients 70 years old or older: a retrospective review of 206 cases. Neuro Oncol. 2011;13(4):428-36.
Okumus NO, Gursel B, Meydan D, Ozdemir O, Odabas E, Gonullu G. Prognostic significance of concomitant radiotherapy in newly diagnosed glioblastoma multiforme: a multivariate analysis of 116 patients. Ann Saudi Med. 2012;32(3):250-5.
Ahmadloo N, Kani AA, Mohammadianpanah M, Nasrolahi H, Omidvari S, Mosalaei A, et al. Treatment outcome and prognostic factors of adult glioblastoma multiforme. J Egypt Natl Canc Inst. 2013;25(1):21- 30.
Henriksson R, Asklund T, Poulsen HS. Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review. J Neurooncol. 2011;104(3):639-46.
Drewes C, Sagberg LM, Jakola AS, Solheim O. Perioperative and postoperative quality of life in patients with glioma—a longitudinal cohort study. World Neurosurg. 2018;117:e465-74.
Sagberg LM, Solheim O, Jakola AS. Quality of survival the first year with glioblastoma: a longitudinal study of patient-reported quality of life. J Neurosurg. 2016;124(4):989-97.
Sacko A, Hou MM, Temgoua M, Alkhafaji A, Marantidou A, Belin C, et al. Evolution of the Karnofsky Performance Status throughout life in glioblastoma patients. J Neurooncol. 2015;122(3):567-73.
McLachlan SA, Devins GM, Goodwin PJ. Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQC30) as a measure of psychosocial function in breast cancer patients. Eur J Cancer. 1998;34(4):510-7.
Leung A, Lien K, Zeng L, Nguyen J, Caissie A, Culleton S, et al. The EORTC QLQ-BN20 for assessment of quality of life in patients receiving treatment or prophylaxis for brain metastases: a literature review. Expert Rev Pharmacoecon Outcomes Res. 2011;11(6):693-700.
Mahalakshmi P, Vanisree AJ. Quality of life measures in glioma patients with different grades: a preliminary study. Indian J Cancer. 2015;52(4):580-5.
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