Seizure Control Effect and Safety of Generic Intravenous Phenytoin Sodium in Patients with Traumatic Brain Injury

Authors

  • Kampanart Hassajinda Division of Neurosurgery, Department of Surgery, Samutprakarn Hospital

Keywords:

post-traumatic seizure, traumatic brain injury, antiepileptic drug, seizure prevention

Abstract

Background: Antiepileptic drug can prevent seizure during the first 7 days (early post-traumatic seizure). Phenytoin is a drug that has been used for a long time and has anti-seizure effect. But when the drug has been changed from the original drug to the generic drug, there may be concerns about the seizure control effect.
Objective: This research is to study the effect of seizure control. Both treatment and prevention and side effects that occur in patients with traumatic brain injury on the generic phenytoin
Methods: Data was retrospectively collected from the medical records of the patients admitted to the hospital. (retrospective cohort study) from 1 January 2021 to 31 December 2021 at Samutprakan hospital. The data was collected about seizures after traumatic brain injury and side effects after taking the medication.
Methods: Data was retrospectively collected from the medical records of the patients admitted to the hospital. (retrospective cohort study) from 1 January 2021 to 31 December 2021 at Samutprakan hospital. The data was collected about seizures after traumatic brain injury and side effects after taking the medication.
Conclusions: In Samutprakan hospital, The generic phenytoin has effect in controlling seizure in patients with traumatic brain injury and no serious complication was found in this research.

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Published

2025-10-03

How to Cite

Hassajinda, K. (2025). Seizure Control Effect and Safety of Generic Intravenous Phenytoin Sodium in Patients with Traumatic Brain Injury. Thai Journal of Neurological Surgery, 14(2), 55–62. retrieved from https://he05.tci-thaijo.org/index.php/TJNS/article/view/6718

Issue

Vol. 14 No. 2 (2023): April-June 2023

Section

Original articles

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