Evaluation of COBAS c111 and COBAS INTEGRA 800 automated analyzers

Abstract

Objective : To evaluate the analytical performance of a small automated analyzer, COBAS c111, in comparison with a single platform analyzer, COBAS INTEGRA 800, from Roche Diagnostics.

Methods : To compare usual biochemistry parameters from both analyzers: substrates (glucose, HbA_1c, BUN, creatinine, uric acid, cholesterol, triglyceride, HDLcholesterol, LDL-cholesterol), electrolytes (sodium, potassium, chloride, bicarbonate), enzymes (AST, ALT, ALP, CK, CK-MB and y-GT), total proteins, albumin. The inter-, intra-variable precisions and comparison analyzers were analyzed.

Results : in inter-, intra-variable precisions study, coefficient of variation (CV,%) of all parameters for precinorm (normal) and precipath (abnormal) control sera were lower than limits suggested by the CLIA’88 performance rules. The comparative study indicated good correlation with COBAS c111 and COBAS INTEGRA 800 and correlation coefficients (r) were above 0.961.

Conclusion : Both analyzers showed satisfactory precision and accuracy and good correlation with each other. They are suitable for routine use in laboratories of different sizes. COBAS c111 is fit to laboratories of small size while COBAS INTEGRA 800 is suitable for medium to laboratories of large size