Weight Outcome Following Treatment of Hyperthyroidism

Abstract

             Hyperthyroidism causes weight loss, but not all patients present with weight loss; about 5–10% of patients describe weight gain at presentation. This study aimed to determine the risk factors for weight gain until they were euthyroid. A retrospective study among adult patients diagnose daccording to ICD–10 including Thyrotoxicosis (E05–E07) in Buddasothorn hospital between 1 June 2018 to 30 September 2022. The information from patients’ medical records was retrieved and analyzed by Chi–square test for association between two categorical factors, and the unpaired Student’s t–test wasused to assess the relationship between continuous and dichotomous and logistic regression.

             The study showed that among 233 thyrotoxicosis patients, most of patients were overweight at diagnosis. The initial mean of body weight and BMI were 60.44 ± 0.79 kg and 23.58 ± 0.28 kg/m², respectively. They had weight gain at the end of treatment especially those with low BMI. The risk factor for increase BMI were the aged < 45 years old at diagnosis (p = 0.0399), BMI < 25 kg/m² at diagnosis (p = 0.0193) and development of hypothyroidism after treatment (p = 0.0069). The logistic regression analysis showed that the patients with a diagnosis of Graves’ hyperthyroidism gained more weightand BMI than those with othercausesof hyperthyroidism (p = 0.0193andp = 0.016, respectively). From thestudyobtained, it can be used as a guideline fo rproviding information to doctors and patients in monitoring and encouraging patients to change their consumption behavior and exercise, to prevent
obesity after treatment.