Correlation between cytology and pathology reports in diagnosis of thyroid carcinoma
Keywords:
Thyroid carcinoma, Cytology, Correlation, Diagnostic Performance, Bethesda system, TBSRTCAbstract
Thyroid cancer diagnosis by needle aspiration and cytological evaluation is a more convenient pathological evaluation method than pathological examination. One particularly common cytological evaluation system is The Bethesda System for Reposting Thyroid Cancer (TBSRTC), which has been used in the United States since 2007 and is widely adopted worldwide. Nevertheless, due to genetic differences and differences in factors that may affect genetics (epigenetics), this study aimed to evaluate the relationship between thyroid cancer results by cytological examination and pathological examination for patients in Sakon Nakhon Province, Thailand.
The study collected data from 372 thyroid tumor patients who underwent cytological examination using the TBSRTC system and received thyroid surgery at Sakon Nakhon Hospital from 2019-2023. Rank biserial correlation analysis found a large correlation between thyroid cancer examination results by cytological examination and pathological examination (coefficient 0.497714, 95% confidence interval 0.343475-0.6519531, large effect size). Analysis of the diagnostic performance found that the cytological examination had a sensitivity of 12.5%, a specificity of 100%, a probability that thyroid cancer patients would be examined by aspirating a needle for cytological examination with a positive predictive value of 100%, a probability that thyroid cancer patients would be examined by aspirating a needle for cytological examination with a negative predictive value of 74.7%, an accuracy of cytological examination of 75%, and a precision of 100%.
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