Clinical Characteristics and Treatment Outcome of Pharyngotonsillar Diphtheria and Carrier of Corynebacterium diphtheriae in Lomkao District, Phetchabun Province, August – September 2012

Authors

  • Sarawut Suwanpatoomlerd Lomkao Crown Prince Hospital, Phetchabun Province
  • Rome Buathong Bureau of Epidemiology, Ministry of Public Health

Keywords:

Diphtheria, Adult, Outbreak, Clinical, Treatment

Abstract

We reported re-emerging 4 confirmed and 1 probable cases of pharyngotosillar diphtheria and 11 carriers of C. diphtheriae in outbreak at Lomkao district, Phetchabun province during August to September 2012. Five patients, aged between 20 to 37 years old, presented with fever, sore throat and white patch over oropharynx without cough and rhinorrhea. All patients had treated with intravenous Penicillin G Sodium with very good outcome. They were discharged from the hospital in a few days with continuing of antibiotics duration for 14 days. The 11 carriers were treated with Erythromycin or Roxithromycin for 10-14 days. Follow up with repeat throat swab culture for C. diphtheriae when completely of treatment, the result were all negative. Roxithromycin was also effective against C. diphtheriae among carriers with highly compliance.

References

Long SS. Diphtheria (Corynebacterium diphtheriae). In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson Textbook of Pediatric, 17th ed. Elsevier Health Sciences; 2007. p.886-9.

Bishai WR, Murphy JR. Diphtheria and Other Infections Caused by Corynebacteria and Related Species. In: Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, et al, editors. Harrison Textbook of Medicine, 18th ed. New York: McGraw-Hill;2011. p.1188-93.

Gilbert DN, Moellering RC Jr, Eliopoulos GM, Chambers HF, Saag MS, editors. The Sanford guide to antimicrobial therapy. 42nd ed. Sperryville, VA: Antimicrobial Therapy, Inc; 2012.

Kneen R, Pham NG, Solomon T, Tran TM, Nguyen TT, Tran BL, et al. Penicillin vs erythromycin in the treatment of diphtheria. Clin Infect Dis 1998 Oct; 27(4): 845-50.

Engler KH, Warner M, George RC. In vitro activity of ketolides HMR 3004 and HMR 3647 and seven other antimicrobial agents against Corynebacterium diphtheriae. J Antimicrob Chemother 2001;47: 27-31.

Sutter RW, Hardy IR, Kozlova IA, Tchoudnaia LM, Gluskevich TG, Marievsky V, Deforest A, Wharton M. Immunogenicity of Tetanus-Diphtheria Toxoids (Td) among Ukrainian Adults: Implications for Diphtheria Control in the Newly Independent States of the former Soviet Union. J Infect Dis 2000;181 Suppl1: S197-202.

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Published

2024-07-07

How to Cite

Suwanpatoomlerd, S., & Buathong, R. (2024). Clinical Characteristics and Treatment Outcome of Pharyngotonsillar Diphtheria and Carrier of Corynebacterium diphtheriae in Lomkao District, Phetchabun Province, August – September 2012. Weekly Epidemiological Surveillance Report, 44(S1), S78-S85. retrieved from https://he05.tci-thaijo.org/index.php/WESR/article/view/2968

Issue

Vol. 44 No. S1 (2013): Supplement - มีนาคม

Section

Original article

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